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By W. H. Sebrell and Robert S. Harris (Eds.)

ISBN-10: 0126337632

ISBN-13: 9780126337631

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Best et al. noted the protective action of choline in diets containing added cholesterol 106· 107 and the pro91 G. B. Ansell and T. Chojnacki, Nature 196, 545 (1962). W. E. M. Lands and I. Merkl, /. Biol. Chem. 238, 898 (1963). 93 M. G. Larrabee, J. O. Klingman, and W. S. Leicht, J. Neurochem. 10, 549 (1963). 94 K. P. Strickland, D. Subrahmanyam, E. T. Pritchard, W. Thompson, and R. J. Rossiter, Biochem. J. 87, 128 (1963). 95 W. Thompson, K. P. Strickland, and R. J. Rossiter, Biochem. J. 87, 136 (1963).

246 40 6. CHOLINE the enzymes that methylate homocystine. 257 The reduction in methionine formation resulting from the feeding of aminopterin was prevented by citrovorum factor. 258 In contrast to the slight influence of a synthetic citrovorum factor, leucovorin, folic acid was necessary for the optimal formation of A^-methylnicotinamide from administered nicotinamide in rats. 259 As in the case of folic acid, B 1 2 has appeared to be involved in both methyl and formate metabolism. Oginsky found B12-deficient rats less able to form methionine from homocystine and either choline or betaine.

57 J. T. Kiyasu and E. P. Kennedy, /. Biol. Chem. 235, 2590 (1960). 58 E. P. Kennedy, Ann. Rev. Biochem. 26, 119 (1957). 59 B. W. Agranoff, R. M. Bradley, and R. O. Brady, /. Biol. Chem. 233, 1077 (1958). 60 W. Thompson, K. P. Strickland, and R. J. Rossiter, Federation Proc. 18, 338 (1959). 61 H. Paulus and E. P. Kennedy, /. Biol. Chem. 235, 1303 (1960). 62 G. Hübscher, R. R. Dils, and W. F. R. Pover, Nature 182, 1806 (1958). 63 J. Y. Kiyasu, R. A. Pieringer, H. Paulus, and E. P. Kennedy, J. Biol.

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The Vitamins. Chemistry, Physiology, Pathology, Methods by W. H. Sebrell and Robert S. Harris (Eds.)


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