Download Capillary Electrophoresis - Mass Spectrometry (CE-MS) by Gerhardus de Jong PDF

By Gerhardus de Jong

ISBN-10: 3527339248

ISBN-13: 9783527339242

ISBN-10: 3527693807

ISBN-13: 9783527693801

ISBN-10: 3527693815

ISBN-13: 9783527693818

ISBN-10: 3527693823

ISBN-13: 9783527693825

ISBN-10: 3527693831

ISBN-13: 9783527693832

This monograph deals the reader an entire evaluate on either ideas and functions of CE-MS. beginning with an introductory bankruptcy on detection in CE, additionally comparable and extra really good thoughts equivalent to electrophoretic and chromatographic preconcentration are mentioned. a different emphasis is wear CE-MS interfaces, that are defined intimately. In a separate bankruptcy, recognition is paid to sheath-liquid interfacing. The advancements and chances of microchip CE-MS also are defined. functions to all proper parts are mentioned in specified chapters, every one written by way of specialists within the respective fields.
along with purposes in pharmaceutical research and bioanalysis, contemporary implementations in foodstuff technology, forensic research, research of intact proteins, metabolomics and proteomics are highlighted. MS is a superbly acceptable detection procedure for CE, as effective separation is coupled to delicate and choice detection. in addition, MS promises constitution info at the separated compounds. CE-MS has now been built right into a robust hyphenated process complementary to LC-MS. This monograph is an designated resource of data for everybody facing and attracted to CE-MS

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Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications

This monograph bargains the reader an entire assessment on either rules and purposes of CE-MS. beginning with an introductory bankruptcy on detection in CE, additionally comparable and extra really good strategies similar to electrophoretic and chromatographic preconcentration are mentioned. a different emphasis is wear CE-MS interfaces, that are defined intimately.

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24, 2730–2734. Nguyen, A. and Moini, M. (2008) Analysis of major protein−protein and protein−metal complexes of erythrocytes directly from cell lysate utilizing capillary electrophoresis mass spectrometry. Anal. , 80, 7169–7173. W. (2010) Performance of a sheathless porous tip sprayer for capillary electrophoresis–electrospray ionization–mass spectrometry of 101. 102. 103. 104. 105. 106. 107. 108. intact proteins. J. Chromatogr. A, 1217, 7605–7611. H. (2015) Quantitative proteomics using ultralow flow capillary electrophoresis–mass spectrometry.

J. Chromatogr. A, 1267, 162–169. , and Li, L. (2015) Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS. Analyst, 140, 467–475. , and Hankemeier, T. (2014) Capillary electrophoresis–mass spectrometry using a flow-through microvial interface for cationic metabolome analysis. Electrophoresis, 35, 1308–1314. J. (2015) High speed capillary zone electrophoresis–mass spectrometry via an electrokinetically pumped sheath flow interface for rapid analysis of amino acids and a protein digest.

Only one of these interfaces (CESI 8000, AB SCIEX) is commercialized and is therefore more widespread in use, yet there has been significant growth in the field of CE-MS. Future commercialization of other CE-MS interfaces would allow for more widespread use by giving options for choosing an interface best suited for the kind of analysis one plans to do. In time, interfaces such as those presented in this chapter may begin to replace the coaxial sheathliquid interface, which is still a standard interface used for many CE-MS applications.

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Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications by Gerhardus de Jong


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