By Alan R. Hauser MD PhD
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Extra info for Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent Second Edition
Aureus and Staphylococcus epidermidis. However, they are unable to bind the PBPs of two special groups of staphylococci called methicillin-resistant S. aureus (MRSA) and methicillin-resistant S. epidermidis (MRSE). OC2H5 FIGURE 5-7. indd 24 R side chain of nafcillin. 12/15/11 2:23 AM CHAPTER 5 Antistaphylococcal Penicillins Table 5-4 ■ Antibiotics that Target the Cell Envelope 25 Antimicrobial Activity of the Antistaphylococcal Penicillins Gram-positive bacteria Some Staphylococcus aureus Some Staphylococcus epidermidis Because they cannot bind the PBPs of MRSA and MRSE bacteria, antistaphylococcal penicillins are inactive against them.
As a result, ceftaroline has excellent activity against aerobic gram-positive cocci, including methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis and penicillin-resistant Streptococcus pneumoniae strains (Table 5-14). Its activities against aerobic gram-negative bacteria are similar to that of cefotaxime and ceftriaxone; it lacks antipseudomonal activity. Ceftaroline also has activity against anaerobic gram-positive bacteria but not against anaerobic gram-negative bacteria.
Mycoplasma spp. Legionella pneumophila Groupings of bacteria used in subsequent chapters. Trafﬁc sign representation of antimicrobial spectrum of activity. ADDITIONAL READINGS For excellent overviews of antibiotics, please see these references: Mandell GL, Bennett JE, Dolin R. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 6th ed. Philadelphia, PA: Elsevier; 2005. Mascaretti OA. Bacteria versus Antibacterial Agents: An Integrated Approach. Washington, DC: ASM Press; 2003.
Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent Second Edition by Alan R. Hauser MD PhD