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By M.D. Fulton Roberts

ISBN-10: 1483256758

ISBN-13: 9781483256757

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I n fact, as will be supported by evidence in the ensuing para- THE Eh COMPLEX 37 graphs, there is reason to believe the order to be DCE. Since the order is probably DCE and since D is the most important of the antigens it would be a small, but rational and desirable, step towards the improvement of notation if all genotypes were expressed in this order. This practice is already gaining ground and will be followed here. TABLE V DCe dee DcE Dee dcE dCe DCE dCE 40-8 per cent 38-9 „ „ 141 „ „ 26 „ „ 12 „ „ 1-0 „ „ 0-2 „ „ exceedingly rare Table V shows the approximate incidence of the eight R h antigen complexes in Britain, and it will be observed t h a t there are three orders of frequency; those t h a t are relatively common, 12 per cent, or over, those of 3 per cent, or less and finally dCE of exceptional rarity.

In 1927 it seemed as though the whole topic had been finished by the demonstration of the two alleles M and N ; and for twenty years this view, based on simple agglutination reactions, was not assailed by any newlyaccruing evidence. But now, more than thirty years later, it has become a mass of arbitrary and, at first sight, unrelated symbols. Admittedly many of them are but temporary labels attached to the antigen until it can be assigned to its appropriate place in the system and a convenient and meaningful sign invoked.

The first of them, the P group, can be disposed of briefly. P was discovered in 1927, and, after the discovery in 1951 of the Jay system (short symbol Tja), it proved that they were related. It seems that the system is analagous to the ABO system and, by discarding the Tj notation, the P notation may be modelled on the ABO group as follows. Those who have no P antigen, who may be referred to as pp, are analagous to Group O and have the naturallyoccurring antibodies anti-P and anti-P! in their serum (just as Group 0 persons have anti-A and anti-A-,^ in the serum).

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An Introduction to Human Blood Groups by M.D. Fulton Roberts

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