By Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)
This quantity provides breakthroughs and methods in affinity capillary electrophoresis to degree and verify the physicochemical and thermodynamic parameters of drug compounds. It discusses recommendations to discover and signify interactions to facilitate advancements in managed drug supply and focusing on.
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Extra info for Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)
Therefore, smaller-diameter capillaries can be used at shorter lengths, which ultimately decreases the separation time. Recently, a lot of work in electrophoretic separation has focused on employing chip-based systems, which beneﬁt from the enhancement of ef- 14 Schiewe ﬁciency at reduced analysis times due to miniaturization (8). The main arguments for electrophoresis on chips are reduced consumables (sample, reagent, mobile phase), leading to lower costs and waste, and increased sample throughput, based on the increase in efﬁciency per unit length and time.
Unfortunately, these methods had not been widely accepted because of the manual operation and lower reproducibility of the paper electrophoresis format. The automated capillary electrophoresis (CE) instrument allows rapid and accurate pKa determination. Beckers et al. showed that thermodynamic pKa (pK tha ) and absolute ionic mobility values of several monovalent weak acids were determined accurately using effective mobility and activity at two pH points (17). Cai et al. reported pKa values of two monovalent weak bases and p-aminobenzoic acid (18).
5 Electropherogram of six sulfur anions illustrating peak fronting [thiosulfate (S2O32Ϫ)] and peak tailing [tetrathionate (S4O2Ϫ 6 )]; for better visibility of peak asymmetry, the perpendicular peak axis is drawn as a solid line. 3. 12 Schiewe modiﬁers to the buffer solution; see also Sec. 1). Both methods can be used to eliminate or reverse the charge on the capillary wall, alter hydrophobicity, and, hence, limit solute adsorption. D. Resolution Capillary zone electrophoresis is a separation technique that beneﬁts from very high efﬁciency, not selectivity.
Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) by Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)